• JoeBigelow@lemmy.ca
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    21 hours ago

    This thread is academia with no tangible experience telling users they are wrong about the drug they use. It’s both hilarious and very concerning. The OP has next to no idea what he is talking about despite claiming to have researched the topic. Perhaps the literature is severely lacking, perhaps the cut and dry nature of research misses a lot of the obvious, I don’t know. But a person claiming to be educated on the subject saying swallowing your dose degrades the chemical, implying it won’t work, concerns me. The further pushing of public myth without substantiation (lipstick bs) makes me concerned about the academic integrity of everything said before. They even admit that they are spreading unverified information. But also, if this is where you’re getting your information about LSD, you’re already on the wrong track. DM me if you want to talk with somebody experienced about LSD.

    • CannonFodder@lemmy.world
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      20 hours ago

      I have no knowledge either way. But what if he’s right and you’ve been wasting half your lsd by swallowing? That would be very sad. Have you tried sticking it in the roof of your mouth, or whatever he’s suggesting?

      • JoeBigelow@lemmy.ca
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        19 hours ago

        Of course I have, when I am certain it’s LSD. There is zero noticeable difference. Hundreds if not thousands of doses, more than a decade of use.

    • daannii@lemmy.worldOP
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      16 hours ago

      Lsd is often distributed and consumed via small paper squares called “tabs” that’s made on blotter paper. The paper is thick like cardstock. Sometimes with colorful psychedelic artwork printed on it.

      The lsd is diluted in a solution and the paper is soaked in the solution.

      The tiny microscopic lsd crystals deposit on the paper. The blotter paper is divided into 1cm squares. Correction. 5mm squares

      Lsd is neutralized by many chemicals , including chlorine (found in tap water) and stomach enzymes. It cannot be swallowed and still have an effect. Unless mixed with other compounds

      To take LSD, a person will place squares (typically one square is 1x 100ug dose) of the paper on the tounge or under it. And hold for about 15 minutes. Some people take more than one. It can’t kill you. But it can lead to accidents in high doses that can kill you. So it’s not risk free even if health risks are low.

      Also I said ug. Not mg. The lsd drug is very unique in that it has high potency at micrograms. Fentanyl is another drug that has that property . But it is rare.

      The lining of the mouth (mucus membranes) allows for easy transfer of the drug into the blood stream. That’s true for a lot of drugs actually.

      This is why lsd has such a unique drug delivery method though. It can’t be swallowed and it should be used in very small doses.

      Lsd is also very resistant to degredation. Oxygen, sunlight, and neutralizing chemicals like chlorine can degrade it. But if it’s stored properly it can last a very very long time. This is another rare property it has.

      It’s also clear, tasteless, and no odor.

      I’m a perception researcher and , of course, this would be a drug on my radar. So I know quite a bit about it. I’ve given a lecture on psychedelics. It’s a fascinating topic.

      Also I’m generally interested in psycho-pharmacology because , well, it’s interesting.

      If you want to learn more interesting facts about LSD and other psychedelics, ask away.

      **Guy in picture has two tabs (squares of blotter paper) on his tongue and is wearing sunglasses because lsd dialates your pupils and makes your eyes sensitive to light.

      • tomiant@piefed.social
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        20 hours ago

        LSD absolutely can be swallowed, I don’t understand where all these myths come from and how they keep being propagated over decades and decades when it is a very simple thing looking it up.

        Also, LSD is not crystallizing onto blotter. It is absorbed into the paper fibers from a solution. That is not how crystallization works.

        Jesus there is more… Chlorine can degrade LSD under certain conditions, but trace chlorine in tap water does NOT reliably neutralize it in vivo.

        Lsd is also very resistant to degredation.

        LSD is chemically fragile. It degrades with light, oxygen, heat, acids, bases, and oxidizers. What you are saying is the opposite of how chemists describe LSD.

        I’m a perception researcher

        lol, sure you are.

        • daannii@lemmy.worldOP
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          16 hours ago

          After re checking this information, I believe I was confusing DMT and LSD properties of not being active when ingested.

          I remembered DMT can’t be ingested but I was sure it was true for LSD. But I was mistaken. LSD is neutralized by base not acids.

      • JoeBigelow@lemmy.ca
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        1 day ago

        Incorrect about acid in the stomach. Most DOX and nbome chems are neutralized by stomach acid and during the mid 2010 acid drought swallowing tabs was considered the simplest way to avoid unwanted DOX trips.

        Source: the hundreds of tabs that I swallowed and still had a good time

        Edit: Tons of chemicals are active on the hundred microgram scale. Most benzos, nearly all psychedelics, a handful of antipsychotics ect. And if we go active at >10mg, which is impossible to dose without a .000 scale, the list gets even bigger. I appreciate the attempt at an informative post but it’s got a few dangerous points of misinformation.

        I’m concerned that somebody giving lectures about this topic is as uninformed as you seem to be. Have you taken acid? The subjective experience is as important as the objective. It’s like listening to my cop uncle talk about weed but couched in academia.

        • Rai@lemmy.dbzer0.com
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          1 day ago

          I took DOC back in the 00s (on purpose) and it was an extremely wild 20-some hours. Second weirdest thing I’ve done (the weirdest is Foxy by a WIDE margin,) but I still had a relatively good time due to having a great and comfortable set and setting. By hour ten, I was VERY ready to be done.

          • JoeBigelow@lemmy.ca
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            1 day ago

            I was too poor to care, been on plenty of non acid trips on chems that lasted wayyy too long. Some were really fun, some were abject terror. Never got to try foxy sadly. MXE was the strangest chem I’ve tried and holey hell, I turned into an interdimentional worm crawling through the multiverse. It was super overwhelming.

            • Rai@lemmy.dbzer0.com
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              21 hours ago

              I never tried MXE! I wanted to as I have enjoyed ket in the past, but the times I was offered MXE, I just eas not in the right headspace/environment.

              Foxy is fucking insane. It had the normal visual and auditory hallucinations, but it’s the only thing I’ve ever tried that gave me full on temporal distortions. My partner-at-the-time and I were listening to familiar music. The music would get lower in pitch and streeeetch out, each individual note playing for longer and longer, until the tone went back to normal and the notes stopped being played for so long. When it was low and slow, our bodies got soooo heavy, we would just lay on the floor. When the notes got fast and higher pitched, our bodies would be light with energy. VERY weird stuff.

              • JoeBigelow@lemmy.ca
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                21 hours ago

                MXE and ket are really different. The hole threshold and the visual nature are way stronger ime

        • daannii@lemmy.worldOP
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          21 hours ago

          Most drugs/medicines are taken in higher doses because the body filters or neutralizes the compounds so much that only a small portion gets into the blood.

          That’s still different.

          Even if the total quantity of the drug is small in the system once it gets there, it’s not the same as how LSD works. The drug, likely because of its similarity to serotonin and size , is readily absorbed into the blood stream and passes the blood brain barrier easily. It is not filtered out to a small percentage of it’s original dose like most drugs/medicines.

          You surely are aware of this ?

          There are very few drugs that can work in small dosages like LSD. As I said, fentanyl is one.

          Drugs like DMT /Ayahuasca also can’t be ingested unless they are mixed with a maoi inhibitor.

          Most psychedelic research chemicals (nbome) are much different than lsd with different pharm and effect properties.

          It’s possible that LSD is released more quickly on the tongue than nbome drugs. So as soon as it hits the tounge the drug is delivered. I don’t think there is research on this. But I’ll look into it. I do know that the first trip was caused by a small contact of the drug on someone’s hand. That the cleaned off immediately. And it was enough time to absorb a substantial amount of the drug.
          I heard women would put on lipstick and smear LSD on the front and kiss police during protest to dose them. If That happened it might support a very fast delivery.
          I can’t find the source right now to verify the story. I’ll keep looking. Maybe I have details wrong. Maybe it was Charles Manson instructing women to do this. Does this story sound familiar to anyone ? I’ll have to find the source and verify.

          But my point is.

          This idea that it’s not neutralized in the stomach is false. There is plenty of research on that.

          • JoeBigelow@lemmy.ca
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            21 hours ago

            Look up Clonazepam, I’m not going to argue with somebody that is as confidently incorrect as you are. I have a decade and a half of subjective experience and personal research into the chemicals I have put into my body, and spent countless hours talking with people that know even more than I do. Yes, LSD is very active in small amounts. So are plenty of other chemicals and calling it unique because of that is incorrect.

            Also, stomach acid does nothing to neutralize LSD in any meaningful way, please stop saying that. You’re entire last 2 paragraphs are unsubstantiated myths and things only squares believe. The amount of LSD that Hoffman splashed on his hand likely contained thousands of doses.

            I HAVE EATEN HUNDREDS IF NOT THOUSANDS OF HITS OF LSD AND SWALLOW ALMOST EVERY SINGLE ONE OF THEM. SWALLOWING LSD DOES NOT PREVENT IT FROM WORKING. I WILL GIVE YOU TABS TO FUCKING TRY IF YOU WANT

      • BlasphemousTiefling@lemmy.ml
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        23 hours ago

        Honestly, damn. That sounds like a very interesting topic. If I wanted to learn more what resources would you recommend? (preferably textbooks/articles)

        • daannii@lemmy.worldOP
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          22 hours ago

          You know there isn’t much in a single location aside from Wikipedia.

          In textbooks I’ve come across , there is discussion of the pharmacology properties or a brief note about counter culture and general effects.

          There is limited research on the drug as it’s been black listed for almost 50 years and even now, it’s primarily only researched for terminally ill people/mental health. Only a handful of those studies exist and none use double blind controls so the science quality is poor.

          I myself am not convinced it has mental health benefits due to the way the drug works. It does however have strong suggestive effects meaning the drug itself promotes placebo/expectation effects.

          The lecture I put together for my class (perception and sensation ) pulled info from a wide range of resources.

          However there is one organization trying it’s best to do modern research and they have done some MRI studies. There was also a study on LSD and synesthesia which sheds a lot of light into the mechanisms. MAPS is the organization. https://maps.org/

          They have videos on YouTube with researchers discussing the research and studies they have done. But they mostly focus (last few years at least) on it’s use in mental health.

          The drug property information I know about is mostly pulled from old research from the 60s before the research bans. A lot was done on animals to understand dosage and half life. The cascade effects of how this drug works are still not really understood. We do know that the drug is similar in structure to serotonin. But there are still a lot of unknowns.

          Let me dig around for my resource links. I have a few interesting studies I found when preparing the lecture, including the synesthesia one, and I’ll organize it all and I’ll put a link up to a g drive with it.

          The lecture I did was 3 hrs long about hallucinations with a chunk dedicated to psychedelics. It did rely on other lecture materials to understand or otherwise id just put it up. (It was the final lecture for the class so it referred back multiple times to previous lessons). But maybe I can re-write it a bit. I’ve honestly been thinking of turning it into a video for a while because there are so few resources out there that review it more broadly. And a hell of a lot of misinformation about hallucinations and psychedelics.

          Basically this lecture was on hallucinations and the primary causes and how each of these causes relies on the same root changes in brain processing.

          For instance. You are driving on a country road at night. Vigilant to look for deer. Multiple times you were sure you saw an animal near the road but soon realized it was a fence post. Or an old glass bottle reflecting your headlamps. But for a split moment you did see an animal there before you corrected the perception.

          What ultimately caused that is what causes hallucinations in other situations. Like schizophrenia and drug use.

          So we circle around neuroscience, psychiatry, physiology, and pharmacology. As well as cultural impacts influencing the experience of hallucinations or psychedelics.

          This is getting long. Apologies. The lecture is 3 hrs and relies on many other hours of information. It’s a big topic.

            • daannii@lemmy.worldOP
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              16 hours ago

              Erowid is personal opinions of drug users.

              I don’t lecture about how much acid you should drop or how to prepare for a trip. I give a lecture on the cognitive and physiological changes the drug causes.

              I use scientific resources.

              Other people are welcome to use personal stories and opinions to inform themselves but we don’t use anecdotes in academia because none of them can be verified and are heavily subjective.

              Doesn’t mean they don’t have value. Doesn’t mean the information is false.

              It just means it’s not scientific.

              • jve@lemmy.world
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                14 hours ago

                Erowid is personal opinions of drug users.

                Among other things, including many links to scientific resources.

                This is such a bad take that I again question your research methods.

      • captainlezbian@lemmy.world
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        23 hours ago

        Wait, is two tabs unusual? Like sure the default among my friends was one, but two is for when you really want to experience it and is more for constructive trips or to hallucinate and three is for when you need even more but you’re playing with fire there

        • daannii@lemmy.worldOP
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          22 hours ago

          I mean it depends on the person and the dose on the tabs. Like most recreational illegal drugs, it’s hard to know how much is actually present on the tabs.

          Many times drugs are diluted at various steps of transport and selling. Though it is harder to do that to a drug already on paper like this.

    • Snot Flickerman@lemmy.blahaj.zone
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      1 day ago

      LSD is often distributed on small pieces of paper that you dose by putting them on your tongue and letting them dissolve.

      It appears that this young man is attempting to “break on through to the other side” so he can “see” Allah.

    • DaGeek247@fedia.io
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      1 day ago

      Well, he has two tabs, so more like two spiritual experiences at the same time instead.